Training and development M The EURL provides scientific and technical assistance to all the NRLs - Organisation of training session on request (in Nancy or in the NRL), with transfer of techniques, - Organisation of workshops with interested NRLs on specific topics, - Establishment of procedures and guidelines, - Providing on-going technical assistance at a distance (phone meetings, e-mails, biological material supplied on request, etc.). IMAGE www.anses.fr   |   Copyright  |   Portal Anses websites IMAGE last update: May 2013 Techniques that could be validated and/or standardised within Member States IMAGE IMAGE IMAGE IMAGE IMAGE IMAGE Methods used for rabies diagnosis: Fluorescent Antibody Test (FAT), Rabies Tissue Culture Infection Test (RTCIT), Mouse Inoculation Test (MIT), Polymerase Chain Reaction (PCR) Method for determining the viral titre of the vaccine in the bait Method for detecting tetracycline (or other biomarker) in the teeth or bones of target species killed in vaccinated areas Method for determining the age of animals tested for biomarker determination Methods for evaluating the stability of baits prior to use in the field Method used for fox serology (ELISA) of orally vaccinated animals Method for determining the potency of inactivated vaccines IMAGE IMAGE IMAGE IMAGE IMAGE Home Rabies disease The lab Duties of the EURL EURL Team presentation Training and development Work on rabies by Nancy laboratory Other international activities NRLs The network National Reference Laboratories presentation EC rules Useful information Links Map and directions Contact us IMAGE IMAGE Contact Sign out News, calendar Documentation Periodical publications Work programmes Technical reports Workshops Proficiency tests Protocols Other documentation Strain database Presentation All data Advanced search in database Submit data Reagents 12/10/2014 1072 26/05/2014
National Reference Laboratories presentation EURL / NRLs presentation M Click on yellow icons to download presentation leaflets of each National Reference Laboratory for rabies. IMAGE   www.anses.fr   |   Copyright  |   Portal Anses websites IMAGE last update: May 2013 IMAGE IMAGE IMAGE IMAGE IMAGE Home Rabies disease The lab Duties of the EURL EURL Team presentation Training and development Work on rabies by Nancy laboratory Other international activities NRLs The network National Reference Laboratories presentation EC rules Useful information Links Map and directions Contact us IMAGE IMAGE Contact Sign out News, calendar Documentation Periodical publications Work programmes Technical reports Workshops Proficiency tests Protocols Other documentation Strain database Presentation All data Advanced search in database Submit data Reagents 12/10/2014 1076 26/05/2014
European Union Reference Laboratory team presentation 17/01/2020 1197 26/05/2014
Training and development The EURL provides scientific and technical assistance to all the National Reference Laboratories (NRLs) ●  Organisation of training sessions on request (in Nancy or in the NRL), with transfer of techniques, ●  Organisation of workshops with interested NRLs on specific topics, ●  Establishment of procedures and guidelines, ●  Providing on-going remote technical assistance (phone meetings, e-mails, biological material supplying on request, etc.). 17/01/2020 1202 26/05/2014
European Commission rules EURLs, what for? .. In the context of the EU strategy aimed at improving animal health and establishing the single market for live animals and animal products, a network of European Union and National Reference Laboratories dealing with major animal diseases has been gradually set up. The designation of European Union Reference Laboratories should contribute to a high quality and uniformity of analytical results. EURLs for animal health and zootechnics are listed in Annex VIII of Regulation (EC) No 882/2004 on official controls, a regulation which was recently repealed and replaced by Regulation (EU) 2017/625 of the European Parliament and of the Council of 15 March 2017, starting 29 April 2018, in order to rationalize and simplify the overall legislative framework, and integrate the rules applicable to official controls in specific areas into a single legislative framework for official controls. Functions and duties of the EURLs consist notably in providing information on analysis methods and organising comparative tests with the National Reference Laboratories, coordinating the application of the methods and research into new analysis methods, organising training and advanced courses for National Reference Laboratory staff and providing scientific and technical assistance to the Commission. Apart from these duties and functions the Commission approves an annual or bi-annual working plan for each EURL specifying their tasks for the next year(s). .. Financial aid to EURLs .. Within the framework of Council Decision 90/424/EEC on expenditure in the veterinary field of 26 June 1990, these laboratories may receive European Union financial aid for fulfilling the tasks and functions specified in the animal health legislation. For this reason, the work programmes for the EURLs concerned are approved every year via specific Decisions, based on Council Decision 90/425/EEC. Appropriations shall be decided upon each year as part of the budgetary procedure. Commission Regulation (EC) No 1754/2006 of 28 November 2006 lays down detailed rules for the granting of European Union financial assistance to European Union Reference Laboratories for feed and food and the animal health sector pursuant to Article 28 of Decision 90/424/EEC. The said Regulation provides that the financial contribution from the European Union is to be granted if the approved work programmes are efficiently carried out and that the beneficiaries supply all the necessary information within certain time limits. In accordance with Article 2 of this Regulation, the relationship between the Commission and each European Union Reference Laboratory is laid down in a partnership agreement which is supported by a multi-annual work programme. .. Eradication and monitoring programmes .. The European Commission has eradication and monitoring programmes for animal diseases (Regulation (EU) N° 652/2014). These national veterinary programmes aim at progressively eliminating animal diseases that are endemic to certain areas of the European Union. They also include checks aimed at preventing zoonoses. The programmes include a wide range of measures including vaccination, testing of animals, compensation for slaughtering or culling and treatment. Rabies is part of the second group of diseases (“diseases with impact on human health and/or animal health and close to eradication, whenfeasible") covered by the EC programmes. .. Task force for monitoring disease eradication in the Member States .. The Task Force was created in a meeting held on 15 March 2000 in Brussels in accordance with action 29 of the White Paper on Food Safety . The objectives of the Task Force are to improve animal disease eradication as well as improve the cost-benefit ratio of animal disease eradication programmes co-financed by the European Union. Meetings are chaired by the Commission and take place in Brussels each three to six months. For some diseases (sheep and goat brucellosis, bovine brucellosis, bovine tuberculosis, rabies, salmonellosis) subgroups of the Task Force have been established. The subgroups support the Task Force and the Member States in their attempts to develop and to implement optimal disease eradication measures. The members of the subgroups are personally nominated. For each meeting of the Subgroups a final report is produced. In those reports, a number of conclusions and recommendations are provided. The Task Force for rabies was created in 2004. Year Date Town Country 2017 2-4 October Bucharest Romania 2015 15-16 October Budapest Hungary 2012 11-12 December Warsaw Poland 2012 29-30 November Zagreb Croatia 2011 28 April Kaliningrad Russia 2011 14-15 March Plovdiv Bulgaria 2010 8-9 November... 10/02/2020 1209 26/05/2014
Strain database presentation Strain database The EURL has developed a database recording epidemiological information on rabies strains including the corresponding Genbank sequence accession number. Linking Genbank numbers to this database will avoid the duplication of information and prevent redundancies for the NRLs since the GenBank database is an appropriate and useful tool already used for publication, research and analysis of sequences. The advantage of the EURL's sequence database is that it will make epidemiological information related to this sequence available. Submit cases Please participate actively in the deployment of the database by filling out the form for each of your new positive cases! Submit data on-line Download strain identification form (pdf, to be sent by mail or email) Consult data All data - strain database direct consultation Advanced search in database 06/08/2014 1232 26/05/2014
European Union Reference Laboratoryteam presentation About the laboratory M The EURL team, under the direction of Dr. Florence Cliquet, has a full time staff of 3 for the Lyssavirus Unit. Director of the EURL for rabies Dr. Florence Cliquet: Senior Scientist; PhD in Immunology; 21 years of experience in rabies; Head of the Lyssavirus unit; Head of the rabies serology EURL and the rabies EURL; Head of the WHO Collaborating Centre; OIE rabies expert Head of rabies E-RL project Dr. Emmanuelle Robardet: Scientist; PhD in Epidemiology; Head of the Rabies EURL Rabies EURL technical scientist Sabrina Andrieu Rabies EURL administrative officer Sylvie Tourdiat The Lyssavirus Unit represented by 15 agents is headed by Dr Florence Cliquet. Each scientist of the Lyssavirus Unit can provide expertise, scientific and technical support under the rabies EURL mandate in accordance with their specialty (diagnosis, molecular biology, bait titration, virology, etc.). Dr. Evelyne Picard-Meyer: Scientist; PhD in molecular biology; 12 years of experience in rabies diagnosis and molecular epidemiology; Deputy Head of the Lyssavirus Unit. Dr. Jacques Barrat: Doctor of Veterinary Medecine; 30 years of experience in rabies; OIE rabies expert; Head of animal experimentation. Marine Wasniewski: Scientific engineer; Head of the Rabies serology EURL; Head of virology section; responsible for immunology work in seroneutralisation tests. Alexandre Servat: Scientific engineer; Head of vaccinology section and diagnosis. Jean-Michel Demerson: Head technician; 25 years of experience in fox ecology and in field rabies oral vaccination programmes using aerial and manual methods. IMAGE Group picture of the Lyssavirus Unit IMAGE Contact us For any enquiry, please contact us by email specifying: - “rabies” in the object - your name, laboratory and function in the message The messages without “rabies” in the object will be destroyed without being read. www.anses.fr   |   Copyright  |   Portal Anses websites IMAGE last update: May 2013 IMAGE IMAGE IMAGE IMAGE IMAGE Home Rabies disease The lab Duties of the EURL EURL Team presentation Training and development Work on rabies by Nancy laboratory Other international activities NRLs The network National Reference Laboratories presentation EC rules Useful information Links Map and directions Contact us IMAGE IMAGE Contact Sign out News, calendar Documentation Periodical publications Work programmes Technical reports Workshops Proficiency tests Protocols Other documentation Strain database Presentation All data Advanced search in database Submit data Reagents 12/10/2014 1071 26/05/2014
titre vide M National Reference Laboratories Network www.anses.fr   |   Copyright  |   Portal Anses websites IMAGE last update: May 2013 IMAGE IMAGE IMAGE IMAGE IMAGE IMAGE Home Rabies disease The lab Duties of the EURL EURL Team presentation Training and development Work on rabies by Nancy laboratory Other international activities NRLs The network National Reference Laboratories presentation EC rules Useful information Links Map and directions Contact us IMAGE IMAGE Contact Sign out News, calendar Documentation Periodical publications Work programmes Technical reports Workshops Proficiency tests Protocols Other documentation Strain database Presentation All data Advanced search in database Submit data Reagents 12/10/2014 1075 26/05/2014
Contact Useful information M For any questions or remarks regarding this website, please contact us by email , specifying: -“rabies” in the object - your name, laboratory and position in the message. Messages without “rabies” in the subject heading will be destroyed without being read. IMAGE www.anses.fr   |   Copyright  |   Portal Anses websites IMAGE last update: May 2013 IMAGE IMAGE IMAGE IMAGE IMAGE Home Rabies disease The lab Duties of the EURL EURL Team presentation Training and development Work on rabies by Nancy laboratory Other international activities NRLs The network National Reference Laboratories presentation EC rules Useful information Links Map and directions Contact us IMAGE IMAGE Contact Sign out News, calendar Documentation Periodical publications Work programmes Technical reports Workshops Proficiency tests Protocols Other documentation Strain database Presentation All data Advanced search in database Submit data Reagents 12/10/2014 1079 26/05/2014
Duties of the European Union Reference Laboratory Coordinating the methods employed in the Member States for diagnosing rabies ●  Typing, storing and supplying strains of rabies virus ●  Preparing, controlling and supplying international standard sera and other reference reagents to the National Reference Laboratories in order to standardise the tests and reagents used in the Member States ●  Validating reference reagents including antigens and national standard sera submitted by the National Reference Laboratories ●  Building up and maintaining a sera bank and a collection of rabies virus, and maintaining a database of strains isolated across the European Union, including typing ●  Organising periodical comparative tests of diagnostic procedures at European Union level and operating laboratory proficiency tests of National Reference Laboratories ●  Collecting and collating data and information on the methods of diagnosis used and the results of tests carried out in the European Union ●  Characterising rabies virus by the most up-to-date methods available to allow a greater understanding of the epidemiology of the disease ●  Keeping abreast of developments in rabies surveillance, epidemiology and prevention throughout the world ●  Acquiring a thorough knowledge of the preparation and use of the products of veterinary immunology used to eradicate and control rabies, including the evaluation of vaccines Contributing to the improvement and  harmonisation of methods of analysis  throughout the European Union ●  By specifying standard test methodologies ●  By providing reference materials to NRLs ●  By providing NRLs with details and guidance on the methods of laboratory analysis, testing or diagnosis ●  By conducting training courses for staff from NRLs, and if needed from other official laboratories Organising workshops for the benefit of National Reference Laboratories ●  Including training of experts from the Member States and, as appropriate, from third countries, in new analytical methodologies Providing scientific and technical assistance to the Commission ●  And, upon its request, by participating in international forums relating to rabies, concerning in particular the standardisation of analytical diagnostic methods and their implementation Performing and coordinating research activities directed towards the improved control and eradication of rabies ●  Carrying out or collaborating with National Reference Laboratories in test validation trials ●  Providing scientific advice to the Commission and collecting information and reports associated with the activities of the European Union Reference Laboratory     MAIN PARTNERS European Commission www.ec.europa.eu OIE - World Organisation for Animal Health www.oie.int WHO - World Health Organisation www.who.int EFSA - European Food Safety Authority www.efsa.europa.eu EDQM - European Directorate for the Quality of Medicines and Healthcare www.edqm.eu FAO -  Food and Agriculture Organisation www.fao.org GARC - Global Alliance for Rabies Control https://rabiesalliance.org/     ADDITIONAL DOCUMENTATION ... European Commission website and regulation   Regulation (EU) 2017/625 of the European Parliament and of the Council of 15 March 2017 (Repeal of Regulation (EC) No 882/2004) Commission Regulation (EC) No 415/2013 of 6 May 2013 (Amendment of  Regulation (EC) No 737/2008) Regulation (EC) No 208/2011 (Amendment of Annex VII to Regulation (EC) No 882/2004) Commission Regulation (EC) No 737/2008 of 28 July 2008 (Nomination of Anses as EURL for rabies) Regulation (EC) No 882/2004 (Official controls) List of European Union Reference Laboratories   Last update : 16 January 2020 16/01/2020 1201 26/05/2014

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